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  • Case 1/2021

MDX: Dog, Extensive left ventricular noncompaction, with severe dilation of the right atrium and endocardial fibroelastosis

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Gross pathology of the heart. a Severe dilation of the right atrium, right atrial appendage and right ventricle, as seen from the right. b An inside view of the right heart showing severe dilation of the right atrium with a dysplastic tricuspid valve consisting of marked hypoplasia of the chordae tendineae, and thick, deformed, and malpositioned valve leaflets. Note the large accessory orifice (arrowhead) of the double-orifice tricuspid valve. The arrow indicates the normal right ventricular inflow tract. c An inside view of the left heart demonstrating the prominent trabeculation of the left ventricular free wall and a marked hypoplastic and branched papillary muscle (Ao, aorta; IVS, interventricular septum; L-At, left atrium; L-Au, left atrial appendage; LV, left ventricle; LV-Fr, left ventricular free wall; PA, pulmonary artery; R-At, right atrium; R-Au, right atrial appendage; RV, right ventricle)

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Histopathologic features of the left ventricular free wall and interventricular septum (a, b) Left ventricular free wall: multiple papillary trabeculae with a broad basis, an increased basophilia and a thick fibrous endocardium. Note that the noncompacted layer is thicker than the compacted one. c Prominent subendocardial fibrosis (asterisk). d Detailed image of the demarked area from image B. The arrows indicate several well-delineated areas of dystrophic mineralization (CL, compacted layer; IVS, interventricular septum; LV, left ventricular free wall; NCL, non-compacted layer)

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